Application | Comment | Organism |
---|---|---|
medicine | Porphyromonas gingivalis-secreted factors may initiate MEK/ERK signal pathways and lead to myocardial cell hypertrophy and apoptosis | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
U0126 | potent MEK-1/2 inhibitor, cellular size, DNA fragmentation, nuclear condensation, and the phosphorylated ERK-1 protein products of H9c2 cells treated with Porphyromonas gingivalis medium, are all significantly reduced after pre-administration of U0126 | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
H9c2 cell | components of Porphyromonas gingivalis spent culture medium not only result in increased total MEK-1 and ERK-1 protein products, but also cause increased cellular size, DNA fragmentation, and nuclear condensation | Rattus norvegicus | - |
myocardium | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
MEK-1 | - |
Rattus norvegicus |
MEK-2 | - |
Rattus norvegicus |
mitogen-activated protein kinase kinase | - |
Rattus norvegicus |